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KMID : 0861120150190010109
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Korean Journal of Oriental Preventive Medicine
2015 Volume.19 No. 1 p.109 ~ p.116
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Effect of pomegranate concentration solution on photoaging
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Kang Su-Jin
Choi Beom-Rak
Kim Seung-Hee
Yi Hae-Yeon
Park Hye-Rim
Song Chang-Hyun
Park Soo-Jin
Ku Sae-Kwang
Lee Young-Jun
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Abstract
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Objective : Solar ultraviolet (UV) light can cause photoaging of human skin. Many researchers have focused on effective prevention to mitigate the aging process. This study was aimed to investigate anti-wrinkle effects of pomegranate concentration solution (PCS) using photoaged hairless mouse model.
Method : To clarify the protective effect of PCS against UVB-induced photo-damage, water capacity was measured with transepidermal water loss (TEWL) in SKH-1 hairless mice. In addition, image of skin replicas was analyzed.
Results : Our results showed that the PCS treatment protects skin against UVB-induced photoaging, based on the parameters including moisture capacity and TEWL. According to visual assessment of skin replica, application of 1 ml/kg PCS inhibited UV-induced wrinkle formation in mice skin as compared to the vehicleapplied control mice.
Conclusion : Taken together, these results indicated that PCS could improve skin wrinkle formation induced by UVB irradiation in SHK-1 hairless mice. PCS could be applied as an anti-wrinkle agent.
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KEYWORD
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photoaging, pomegranate concentration solution, SKH-1 hairless mice, anti-wrinkle agent
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